Onoda K, Kondo C, Mizumoto T, Kusagawa H, Katayama Y, Hayashi T, Komada T, Hirano R, Miyamura T, Tanaka J
Department of Thoracic Surgery, Mie University School of Medicine, Japan.
Artif Organs. 1994 Sep;18(9):706-10. doi: 10.1111/j.1525-1594.1994.tb03404.x.
A comparative study of a newly developed impeller-type centrifugal pump, Nikkiso HMS-15, was made to assess the effects on hemolysis, platelet function, and renal function for extracorporeal circulation (ECC) during open heart surgery. The Bio-pump (cone-type, Medtronic) and the roller pump were used as controls. The increase of serum hemoglobin level in the Nikkiso pump was significantly lower than that in the other pumps. The decrease of platelet counts was recognized after the initiation of ECC in the three pumps whereas the levels of platelet factor 4 and beta-thromboglobulin in the Nikkiso pump group increased by far less than in the other two groups. Moreover, renal function was better maintained in the Nikkiso pump group; in particular, a significantly higher urine output was recorded during ECC and for 1 h after the termination of ECC. The results of our clinical studies suggest that the Nikkiso centrifugal pump is suitable for ECC during open heart surgery.
对新开发的叶轮式离心泵Nikkiso HMS-15进行了一项比较研究，以评估其在心脏直视手术体外循环（ECC）期间对溶血、血小板功能和肾功能的影响。使用Bio-pump（锥形，美敦力公司）和滚压泵作为对照。Nikkiso泵中血清血红蛋白水平的升高明显低于其他泵。在三个泵开始ECC后均发现血小板计数下降，而Nikkiso泵组中血小板因子4和β-血小板球蛋白的水平升高幅度远低于其他两组。此外，Nikkiso泵组的肾功能得到了更好的维持；特别是在ECC期间和ECC结束后1小时记录到明显更高的尿量。我们的临床研究结果表明，Nikkiso离心泵适用于心脏直视手术期间的ECC。
