Pecci L, Fontana M, Montefoschi G, Cavallini D
Dipartimento di Scienze Biochimiche A. Rossi Fanelli, Università di Roma La Sapienza, Italy.
Biochem Biophys Res Commun. 1994 Nov 30;205(1):264-8. doi: 10.1006/bbrc.1994.2659.
In contrast with other inhibitors of the NADH dehydrogenase of the respiratory chain, the decarboxylated dimer of aminoethylcysteine ketimine protects bovine heart submitochondrial particles (SMP) from the NADH-Fe(+3)-ADP-induced lipid peroxidation. This effect, measured as inhibition of malondialdehyde formation, is concentration-dependent in the range 0.02-0.2 mM. This range of concentration is not inhibitory on NADH-oxidase activity of SMP. Furthermore the dimer is able to counteract the malondialdehyde formation stimulated by the Complex I inhibitors rotenone and N-methyl-4-phenylpyridinium (MPP+).
与呼吸链NADH脱氢酶的其他抑制剂相比，氨基乙基半胱氨酸酮亚胺的脱羧二聚体可保护牛心亚线粒体颗粒（SMP）免受NADH-Fe(+3)-ADP诱导的脂质过氧化作用。以丙二醛形成的抑制作用来衡量，这种效应在0.02-0.2 mM范围内呈浓度依赖性。该浓度范围对SMP的NADH氧化酶活性没有抑制作用。此外，该二聚体能够抵消由复合物I抑制剂鱼藤酮和N-甲基-4-苯基吡啶鎓（MPP+）刺激产生的丙二醛形成。
