Dooley T P, Mitchison H M, Munroe P B, Probst P, Neal M, Siciliano M J, Deng Z, Doggett N A, Callen D F, Gardiner R M
Department of Genetics, Sowthwest Foundation for Biomedical Research, San Antonio, Texas.
Biochem Biophys Res Commun. 1994 Nov 30;205(1):482-9. doi: 10.1006/bbrc.1994.2691.
The cytosolic phenol sulphotransferase gene (STP) was mapped to a region of chromosome 16, within the interval defined by human-rodent somatic cell hybrid breakpoints CY160(D) and CY12, which contains FRA16E. YAC and cosmid clones from this 16p interval were screened for the presence of STP. Two non-overlapping cosmid contigs were identified which contain STP-like sequences. Sequencing of these STP-like sequences confirmed that STP is contained within contig 343.1 and maps proximal to FRA16E, and that a related sulphotransferase STM, encoding the catecholamine-sulphating enzyme, is contained within contig 55.4 and maps to the adjacent hybrid interval CY12-CY180A. Thus two phenol sulphotransferase genes (STP and STM) have been finely localised to chromosome 16p12.1-p11.2, to the same region as CLN3, the gene for Batten disease. Both genes are therefore candidate genes for Batten disease.
