Queizán A, Carrero M C, Perdiguero M M, Santamaría L, Candelas S, Nistral M, Codesal J
Departamento de Cirugía Pediátrica, Hospital Infantil La Paz, Madrid.
Cir Pediatr. 1994 Jul;7(3):137-9.
A immunocytochemical study for detection of proliferating cell nuclear antigen (PCNA) in order to quantify the number of PCNA-positive spermatogonia, and cytophotometric determination of spermatogonial DNA were performed in cryptorchid and control testes. The number of PCNA-positive spermatogonia, and the average DNA content of spermatogonia in the cryptorchid testes were altered from first years of age. These precocious spermatogonial alterations suggest that the early surgical testicular descent doesn't prevent lesions of germ cells.
为了量化增殖细胞核抗原（PCNA）阳性精原细胞的数量，对隐睾和对照睾丸进行了检测PCNA的免疫细胞化学研究，并对精原细胞进行了细胞光度法DNA测定。从一岁起，隐睾睾丸中PCNA阳性精原细胞的数量以及精原细胞的平均DNA含量就发生了变化。这些精原细胞的早熟改变表明，早期手术睾丸下降并不能预防生殖细胞的损伤。
