Dennerstein G J, Scurry J P, Garland S M, Brenan J A, Fortune D W, Sfameni S F, O'Keefe R J, Tabrizi S N
Dermogynaecology Clinic, Mercy Hospital for Women, Melbourne, Australia.
Br J Obstet Gynaecol. 1994 Nov;101(11):992-8. doi: 10.1111/j.1471-0528.1994.tb13046.x.
To determine whether human papillomavirus (HPV) was responsible for symptoms in women with vulvar pruritus, pain and superficial dyspareunia who had been referred with a diagnosis of HPV vulvar disease made on clinical and/or colposcopic and/or histological grounds.
In addition to standard clinical and laboratory investigations of the whole population, a sample of 15 test cases from the population of 71 women referred with a clinicopathological diagnosis of HPV vulvar disease, and two positive and 21 negative controls were assayed for HPV DNA. Polymerase chain reaction assays using L1 consensus primers were performed blinded to the clinicopathological diagnosis.
Dermogynaecology Clinic at Mercy Hospital for Women.
Seventy-one women referred with a diagnosis of HPV vulvar disease.
Thirteen cases which could be tested for HPV DNA were negative. Diagnoses other than HPV were found for the women's presentation in all cases.
In the population studied, our investigations indicated that the clinicopathological diagnosis of HPV infection was incorrect and that HPV was not a cause of vulvar symptoms. We believe that the term HPV vulvitis is unfortunate as it has invited destructive treatments and drawn attention away from more likely causes of this difficult group of vulvar conditions.
确定人乳头瘤病毒（HPV）是否为因外阴瘙痒、疼痛和浅表性交困难而转诊的女性出现症状的原因，这些女性已根据临床和/或阴道镜检查和/或组织学检查诊断为HPV外阴疾病。
除了对整个人群进行标准的临床和实验室检查外，还对71例经临床病理诊断为HPV外阴疾病的女性中的15例测试病例样本以及2例阳性和21例阴性对照进行了HPV DNA检测。使用L1共有引物进行聚合酶链反应检测，检测过程对临床病理诊断结果保密。
仁慈妇女医院皮肤科妇科诊所。
71例被诊断为HPV外阴疾病的女性。
13例可进行HPV DNA检测的病例结果为阴性。所有病例中，女性症状的诊断均非HPV感染。
在本研究人群中，我们的调查表明HPV感染的临床病理诊断是错误的，HPV并非外阴症状的病因。我们认为“HPV外阴炎”这一术语并不恰当，因为它引发了破坏性的治疗方法，并使人们的注意力从导致这一复杂外阴疾病组的更可能病因上转移开。
