MacNeill A L, Dick W C
J Int Med Res. 1976;4(2 Suppl):23-7.
It has been reported that imipramine reduces the titre of rheumatoid factor in schizophrenic patients. Twenty out-patients suffering from classical rheumatoid arthritis and having rheumatoid factor titre equal to, or greater than 1:64, were treated in a double-blind trial with imipramine 75 mg or matching placebo. In this study the dose of imipramine used failed to affect the levels of rheumatoid factor.
据报道，丙咪嗪可降低精神分裂症患者类风湿因子的滴度。20名患有典型类风湿性关节炎且类风湿因子滴度等于或大于1:64的门诊患者，在一项双盲试验中接受了75毫克丙咪嗪或匹配安慰剂的治疗。在这项研究中，所使用的丙咪嗪剂量未能影响类风湿因子水平。
