在普通医疗实践中进行的氟考芬那酯与其他四种镇痛药的双盲对照临床试验。

A double-blind comparative clinical trial of floctafenine and four other analgesics conducted in general practice.

作者信息

Lomas D M, Gay J, Midha R N, Postlethwaite D L

出版信息

J Int Med Res. 1976;4(3):179-82. doi: 10.1177/030006057600400306.

Abstract

Three hundred and twelve patients suffering from painful conditions were admitted to a multicentre, double-blind controlled trial, conducted in general practice in which five analgesics--floctafenine (Idarac), paracetamol, aspirin, dihydrocodeine and pentazocine--were compared. Overall ratings of analgesic effect placed floctafenine first in rank order. Floctafenine was statistically significantly superior in effect to pentazocine but not to the other three agents as far as doctor ratings were concerned; and superior to both pentazocine and dihydrocodeine in the opinion of patients. Fewer patients experienced side-effects on floctafenine than on the other four analgesics and this difference between floctafenine and pentazocine, and floctafenine and dihydrocodeine was statistically significant.

摘要

312名患有疼痛病症的患者被纳入一项多中心双盲对照试验，该试验在普通医疗环境中进行，对五种镇痛药——氟洛芬（伊达拉克）、对乙酰氨基酚、阿司匹林、二氢可待因和喷他佐辛——进行了比较。镇痛效果的总体评分显示氟洛芬排名第一。就医生的评分而言，氟洛芬在效果上比喷他佐辛有统计学意义上的显著优势，但与其他三种药物相比无显著差异；而在患者看来，氟洛芬比喷他佐辛和二氢可待因都更具优势。与其他四种镇痛药相比，服用氟洛芬出现副作用的患者较少，氟洛芬与喷他佐辛以及氟洛芬与二氢可待因之间的这种差异具有统计学意义。