Zickmann B, Boldt J, Wulf K, Hofmann H C, Thiel A, Hempelmann G
Abteilung Anästhesiologie und Operative Intensivmedizin, Justus-Liebig-Universität Giessen.
Anasthesiol Intensivmed Notfallmed Schmerzther. 1994 Oct;29(6):330-7. doi: 10.1055/s-2007-996754.
The effects on cerebral function of premedication with the benzodiazepine flunitrazepam and with morphine were studied on the evening of the preoperative day (2 mg flunitrazepam p.o.) and 90 minutes before induction of anaesthesia (2 mg flunitrazepam plus 15 mg morphine i.m.).
The EEG was analysed topographically (17 electrodes) and quantitatively.
As a typical effect of benzodiazepines, increases in electrical activity in the frequency band beta-1 of the power spectrum were observed, and could be demonstrated 10 minutes after oral application, mainly in the frontal and central parts of the cortex. Increases in the powerbands delta and theta indicated induction of sleep approximately 15-20 minutes after application and were not looked upon as an effect of the benzodiazepine exclusively. These increases were noticed first in the central, occipital and temporal areas and after 30 minutes in the frontal parts of the cortex. Flunitrazepam plus morphine showed qualitatively similar but quantitatively less pronounced results. Topographical differences were similar to the results of an application of flunitrazepam alone.
The results demonstrate the importance of a topographical as well as quantitative evaluation in studies on complex interactions of sedative or narcotic drugs and their clinical effects on cerebral function.
研究术前一天晚上口服苯二氮䓬类药物氟硝西泮（2mg口服）以及麻醉诱导前90分钟肌肉注射氟硝西泮（2mg）加吗啡（15mg）对脑功能的影响。
采用17电极对脑电图进行地形图分析和定量分析。
作为苯二氮䓬类药物的典型效应，观察到功率谱β-1频段的电活动增加，口服后10分钟即可出现，主要位于皮质的额叶和中央区。δ和θ频段功率增加表明用药后约15 - 20分钟诱导睡眠，且这并非仅由苯二氮䓬类药物所致。这些增加首先出现在中央、枕叶和颞叶区域，30分钟后出现在皮质额叶部分。氟硝西泮加吗啡显示出定性相似但定量上不太明显的结果。地形图差异与单独应用氟硝西泮的结果相似。
结果表明，在研究镇静或麻醉药物的复杂相互作用及其对脑功能的临床影响时，地形图评估和定量评估都很重要。
