Mariotti A
Department of Periodontology and Pharmacology, J. Hillis Miller Health Science Center, University of Florida, Gainesville 32610.
Crit Rev Oral Biol Med. 1994;5(1):27-53. doi: 10.1177/10454411940050010201.
The biological changes that occur in tissues of the periodontium during puberty, the menstrual cycle, pregnancy, menopause, and oral contraceptive use have heightened interest in the relationship between sex steroid hormones and periodontal health. These clinical observations coupled with tissue specificity of hormone localization, identification of hormone receptors, as well as the metabolism of hormones have strongly suggested that periodontal tissues are targets for androgens, estrogens, and progestins. The etiologies of periodontal endocrinopathies are diverse; nonetheless, periodontal pathologies may be a consequence of the actions and interactions of sex steroid hormones on specific cells found in the periodontium.
在青春期、月经周期、怀孕、更年期以及使用口服避孕药期间，牙周组织中发生的生物学变化引发了人们对性类固醇激素与牙周健康之间关系的浓厚兴趣。这些临床观察结果，再加上激素定位的组织特异性、激素受体的鉴定以及激素的代谢，有力地表明牙周组织是雄激素、雌激素和孕激素的作用靶点。牙周内分泌病的病因多种多样；尽管如此，牙周病变可能是性类固醇激素对牙周特定细胞的作用及相互作用的结果。
