来自HIV-1感染个体和未感染个体的纯化免疫球蛋白G对免疫激活的影响。

Effect of purified IgGs from HIV-1-infected and non infected individuals on immune activation.

作者信息

Chams V, Biou D, Cho Y Y, Mbika J P, Le Coq H, Heshmati F, Fouchard M, Bizzini B, Zagury J F

机构信息

Laboratoire de Physiologie Cellulaire, Université P & M Curie, Paris, France.

出版信息

Biomed Pharmacother. 1994;48(5-6):267-72. doi: 10.1016/0753-3322(94)90143-0.

DOI:10.1016/0753-3322(94)90143-0

PMID:7999989

Abstract

The purification and analysis of IgGs from sera of HIV-1-infected and non infected individuals are reported. The effect of antibodies purified from sera of infected individuals on antigen-induced T cell proliferation was investigated in relation to their possible involvement in an autoimmune reaction in AIDS, in view of the previously unravelled striking peptide similarities between HIV-1 gp120 and the immunoregulatory CD4 and Fas molecules. However, our data do not allow definite conclusions to be drawn. The necessity of purifying antibodies against specific peptides to show their direct effect on T-cell activation is further stressed.

摘要

报告了从感染和未感染HIV-1个体的血清中纯化和分析IgG的情况。鉴于先前发现的HIV-1 gp120与免疫调节性CD4和Fas分子之间惊人的肽相似性，研究了从感染个体血清中纯化的抗体对抗原诱导的T细胞增殖的影响，以及它们可能参与艾滋病自身免疫反应的情况。然而，我们的数据无法得出明确结论。进一步强调了纯化针对特定肽的抗体以显示其对T细胞活化直接作用的必要性。