Duthie G G, Beattie J A, Arthur J R, Franklin M, Morrice P C, James W P
Rowett Research Institute, Aberdeen, Scotland, United Kingdom.
Nutrition. 1994 Jul-Aug;10(4):313-6.
We tested the antioxidant hypothesis of coronary heart disease (CHD) by comparing blood antioxidants, indices of lipid peroxidation and classic (CHD) risk factors of 25 subjects with stable angina pectoris with 200 matched controls. Angina subjects had significantly increased plasma concentrations of total cholesterol, low density lipoproteins and triglycerides although body mass index, plasma cotinine concentration and blood pressure were similar to those of the control group. Plasma concentrations of vitamin A, vitamin C and cholesterol- adjusted vitamin E did not differ between the groups although subjects with angina had significantly decreased plasma uric acid concentrations and elevated indices of lipid peroxidation. Although the results are compatible with the antioxidant hypothesis, it is unclear whether the increased oxidative stress in angina sufferers is a cause or consequence of the disease.
我们通过比较25名稳定型心绞痛患者与200名匹配对照者的血液抗氧化剂、脂质过氧化指标和经典冠心病风险因素，来检验冠心病的抗氧化假说。心绞痛患者的总胆固醇、低密度脂蛋白和甘油三酯的血浆浓度显著升高，尽管其体重指数、血浆可替宁浓度和血压与对照组相似。两组间维生素A、维生素C和经胆固醇校正的维生素E的血浆浓度无差异，尽管心绞痛患者的血浆尿酸浓度显著降低，脂质过氧化指标升高。虽然结果与抗氧化假说相符，但尚不清楚心绞痛患者氧化应激增加是该病的原因还是结果。
