Hartung J, Ying H, Weinberger J, Cottrell J E
Department of Anesthesiology, SUNY-Health Science Center, Brooklyn.
J Neurosurg Anesthesiol. 1994 Oct;6(4):254-9. doi: 10.1097/00008506-199410000-00005.
Hypothesizing that propofol's pro and anticonvulsant effects might be dose dependent, we determined the effect of 25, 50, and 100% of a previously determined anesthetic dose of propofol for rats on the amount of lidocaine required to induce seizures. Lidocaine was infused at 2.5 mg kg-1 min-1 into animals that were receiving either (a) 70% N2O balance O2 (n = 10), control group, (b) 2 mg kg-1 bolus followed by 12 mg kg-1 h-1 propofol infusion with 70% N2O (n = 10), group 2, (c) 4 mg kg-1 followed by 24 mg kg-1 h-1 propofol with 70% N2O (n = 20), group 3, (d) 8 mg kg-1 followed by 48 mg kg-1 h-1 propofol with 70% N2O (n = 10), group 4, or (e) 8 mg kg-1 followed by 48 mg kg-1 h-1 propofol without N2O (n = 10), group 5. Temperature PaCO2, and pH were maintained within normal limits until disturbed by seizure activity or lidocaine toxicity. The plasma concentration of lidocaine required to induce electroencephalographically (EEG) detected seizures was 8.7 +/- 0.7 micrograms ml-1 in control animals, 16 +/- 1.7 micrograms ml-1 in group 2, and 32 +/- 4 micrograms ml-1 in 13 animals from group 3 that experienced a seizure (p < 0.01). Seizures did not occur in seven of 20 group 3 rats.(ABSTRACT TRUNCATED AT 250 WORDS)
假设丙泊酚的促惊厥和抗惊厥作用可能具有剂量依赖性，我们确定了先前确定的大鼠丙泊酚麻醉剂量的25%、50%和100%对诱发癫痫所需利多卡因量的影响。以2.5mg·kg⁻¹·min⁻¹的速度向接受以下处理的动物输注利多卡因：(a)70%N₂O平衡O₂（n = 10），对照组；(b)2mg·kg⁻¹推注，随后以12mg·kg⁻¹·h⁻¹的速度输注丙泊酚并吸入70%N₂O（n = 10），第2组；(c)4mg·kg⁻¹推注，随后以24mg·kg⁻¹·h⁻¹的速度输注丙泊酚并吸入70%N₂O（n = 20），第3组；(d)8mg·kg⁻¹推注，随后以48mg·kg⁻¹·h⁻¹的速度输注丙泊酚并吸入70%N₂O（n = 10），第4组；或(e)8mg·kg⁻¹推注，随后以48mg·kg⁻¹·h⁻¹的速度输注丙泊酚且不吸入N₂O（n = 10），第5组。在癫痫活动或利多卡因毒性干扰之前，将体温、动脉血二氧化碳分压和pH维持在正常范围内。对照组动物诱发脑电图（EEG）检测到癫痫所需的利多卡因血浆浓度为8.7±0.7μg/ml，第2组为16±1.7μg/ml,第3组中13只发生癫痫的动物为32±4μg/ml（p<0.01）。第3组20只大鼠中有7只未发生癫痫。（摘要截断于250字）
