Gonzalez-Juanatey J R, Garcia-Bengoechea J B, Vega M, Rubio J, Sierra J, Duran D, Amaro A, Gil M
Department of Cardiology, Hospital Xeral de Galicia, University of Santiago, School of Medicine, Spain.
J Heart Valve Dis. 1994 Sep;3(5):548-55.
Echocardiography was performed in 94 patients with a total of 99 normally functioning Labcor-Santiago bioprostheses, 62 in the aortic and 37 in the mitral position. The following variables were measured: peak and mean transvalvular velocities, peak and mean instantaneous pressure gradients as calculated from the modified Bernoulli equation, pressure half-time, cardiac index, stroke volume and effective orifice area (using continuity and Hatle equations). Regurgitation patterns were sought by transthoracic echocardiography (all valves) and, for selected mitral bioprostheses, by transesophageal echocardiography. Calculated mean aortic pressure gradient ranged from six to 10 mmHg and calculated effective aortic orifice area increased with ring diameter, with means of 1.27 cm2 for the 19 mm valve and 2.58 cm2 for the 27 mm valve. For mitral bioprostheses, mean pressure gradient ranged from 3.0 to 4.5 mmHg and calculated effective orifice area from 2.27 to 2.73 cm2. Only central regurgitation was observed. The Labcor-Santiago pericardial bioprostheses created little resistance to forward flow. In the small aortic root their hemodynamic performance was as good or better than that of other currently available devices. It is hoped that this new design will contribute increased in vivo mechanical durability.
对94例患者的99个功能正常的Labcor - 圣地亚哥生物瓣膜进行了超声心动图检查，其中62个位于主动脉位置，37个位于二尖瓣位置。测量了以下变量：跨瓣峰值和平均流速、根据改良伯努利方程计算的峰值和平均瞬时压力梯度、压力减半时间、心脏指数、每搏量和有效瓣口面积（使用连续性方程和哈特方程）。通过经胸超声心动图（所有瓣膜）以及对选定的二尖瓣生物瓣膜通过经食管超声心动图寻找反流模式。计算出的平均主动脉压力梯度范围为6至10 mmHg，计算出的有效主动脉瓣口面积随瓣环直径增加，19 mm瓣膜的平均值为1.27 cm²，27 mm瓣膜的平均值为2.58 cm²。对于二尖瓣生物瓣膜，平均压力梯度范围为3.0至4.5 mmHg，计算出的有效瓣口面积为2.27至2.73 cm²。仅观察到中心反流。Labcor - 圣地亚哥心包生物瓣膜对正向血流产生的阻力很小。在小主动脉根部，其血流动力学性能与目前其他可用装置一样好或更好。希望这种新设计将有助于提高体内机械耐久性。
