Morales P, Cordero P, Borro J M, Macián V, Marco V
Servicios de Neumología, Hospital Universitario La Fe, Valencia.
Arch Bronconeumol. 1994 Nov;30(9):440-4. doi: 10.1016/s0300-2896(15)31016-4.
We aimed to assess breathing pattern at rest by studying occlusion pressure after the first 100 miliseconds (P0.1) and ventilatory response to hypercapnia after lung transplantation. Seven transplanted patients were compared with a control group of 7 healthy subjects. The breathing pattern at rest after transplantation included a significant increase in minute volume (VE) at the expense of an increase in tidal volume (VT) and above all of mean inspiratory flow (VT/Ti). There were no significant differences in ventilatory response to hypercapnia between the 2 groups, although the response curves of both VE and VT to CO2 tended to slope downward. These results can be explained by the mechanics of ventilation in some subjects studied and by the effect of pulmonary denervation on ventilatory control.
我们旨在通过研究肺移植后最初100毫秒的阻断压力（P0.1）来评估静息呼吸模式以及对高碳酸血症的通气反应。将7例移植患者与7名健康受试者组成的对照组进行比较。移植后静息呼吸模式包括分钟通气量（VE）显著增加，这是以潮气量（VT）增加，尤其是平均吸气流量（VT/Ti）增加为代价的。两组对高碳酸血症的通气反应无显著差异，尽管VE和VT对二氧化碳的反应曲线都倾向于向下倾斜。这些结果可以用部分研究对象的通气力学以及肺去神经支配对通气控制的影响来解释。
