Sato P, Sargur M, Schoene R B
Chest. 1986 Jun;89(6):828-31. doi: 10.1378/chest.89.6.828.
Hypnosis is an induced state of heightened suggestibility during which certain physiologic variables can be altered. To investigate if carbon dioxide (CO2) chemosensitivity could be blunted during this suggestible state, we measured hypercapnic ventilatory response (HCVR, delta VE/delta PaCO2), oxygen consumption (VO2), breathing pattern (VT and f), inspiratory flow rate (VT/Ti), and inspiratory timing (Ti/Ttot) in 20 healthy subjects. Mouth occlusion pressures (P0.1) were measured in the last nine subjects. Resting oxygen consumption and minute ventilation were measured during awake and hypnotic control states. The HCVR was measured spontaneously and with the suggestion to maintain normal ventilation during both awake and hypnotic conditions. It was found that without a change in metabolism, ventilatory responses to CO2 could be blunted both voluntarily, and to a greater degree, with hypnotic suggestion. These findings may have important implications in clinical settings in which patients suffer from marked dyspnea secondary to increased ventilatory chemosensitivity.
催眠是一种诱导产生的易受暗示性增强的状态，在此期间某些生理变量会发生改变。为研究在这种易受暗示状态下二氧化碳（CO2）化学敏感性是否会减弱，我们测量了20名健康受试者的高碳酸通气反应（HCVR，即ΔVE/ΔPaCO2）、耗氧量（VO2）、呼吸模式（潮气量VT和呼吸频率f）、吸气流量（VT/Ti）以及吸气时间（Ti/Ttot）。对最后9名受试者测量了口腔阻断压（P0.1）。在清醒和催眠对照状态下测量静息耗氧量和分钟通气量。在清醒和催眠条件下，分别自发测量以及在暗示保持正常通气的情况下测量HCVR。结果发现，在代谢无变化的情况下，对CO2的通气反应既能通过自主方式减弱，且在催眠暗示下减弱程度更大。这些发现可能对临床环境具有重要意义，在这些临床环境中，患者因通气化学敏感性增加而患有明显的呼吸困难。
