Sahasrabudhe D M, Dusel J C
Cancer Center, University of Rochester School of Medicine and Dentistry, New York 14642.
Cancer Immunol Immunother. 1994 Dec;39(6):360-6. doi: 10.1007/BF01534422.
T-lymphocyte-mediated immunosuppression has been described in several animal models and in man. In animal models. T-cell-mediated immunosuppression can hasten the development of cancers, permit the growth of tumors in immunocompetent hosts, and inhibit otherwise effective antitumor immunotherapy. Cyclophosphamide can abrogate the T-cell-mediated immunosuppression. However, inappropriately administered cyclophosphamide can adversely affect antitumor immunity. On the basis of data showing that interferon alpha/beta (IFN alpha/beta) and IFN beta selectively abrogate the T-cell-mediated dinitrofluorobenzene-specific suppressor function, we investigated the efficacy of purified murine IFN alpha/beta in manipulating tumor-induced T-cell-mediated immunosuppression in the well-characterized P815 mastocytoma model. In this model, generation of cytotoxicity in vitro and its inhibition by T cells correlates with antitumor immunity in vivo. We report that IFN alpha/beta selectively diminishes the generation of tumor-induced suppressor activity.
T淋巴细胞介导的免疫抑制已在多种动物模型和人类中得到描述。在动物模型中，T细胞介导的免疫抑制可加速癌症的发展，使肿瘤在免疫活性宿主中生长，并抑制原本有效的抗肿瘤免疫治疗。环磷酰胺可消除T细胞介导的免疫抑制。然而，不当使用环磷酰胺会对抗肿瘤免疫产生不利影响。基于显示α/β干扰素（IFNα/β）和IFNβ可选择性消除T细胞介导的二硝基氟苯特异性抑制功能的数据，我们在特征明确的P815肥大细胞瘤模型中研究了纯化的鼠IFNα/β在调控肿瘤诱导的T细胞介导的免疫抑制方面的功效。在该模型中，体外细胞毒性的产生及其被T细胞抑制与体内抗肿瘤免疫相关。我们报告称，IFNα/β可选择性降低肿瘤诱导的抑制活性的产生。
