Gisselsson H, Birkhed D, Björn A L
Department of Cariology, Faculty of Odontology, Göteborg University, Sweden.
Caries Res. 1994;28(5):394-9. doi: 10.1159/000262008.
The aim was to evaluate the effect of chlorhexidine gel treatment on the incidence of approximal caries in preschool children. One hundred and seventeen 4-year-olds, divided into two groups, participated: (1) chlorhexidine gel group (n = 59), and (2) placebo gel group (n = 58). Group 1 was treated 4 times a year with a 1% chlorhexdine gel and group 2 with a placebo gel. Approximately 0.7 ml of gel was applied interdentally by means of a flat dental floss. A control group (group 3), which did not receive any flossing or gel treatment, was also included in the study (n = 116). After 3 years, i.e. when the children were 7 years old, the mean incidence of caries on approximal surfaces (defs), including both enamel and dentin lesions, was 2.59 in the chlorhexidine gel, 4.53 in the placebo gel and 4.20 in the control group (group 1 vs. 2 and group 1 vs. 3: p < 0.01). Mean number of approximal fillings at the end of the study, i.e. when the children were 7 years old, was 0.33 in the chlorhexidine gel, 1.04 in the placebo gel and 0.80 in the control group (group 1 vs. 2: p < 0.01; group 1 vs. 3: p < 0.05). The progression of approximal caries lesions, diagnosed on bitewing radiographs from the age of 5 to 7, was slower in the chlorhexidine than in the placebo gel group (the control group was not evaluated in this respect). A cost analysis, based on the total treatment time in minutes, showed a small gain for the flossing program.(ABSTRACT TRUNCATED AT 250 WORDS)
目的是评估洗必泰凝胶治疗对学龄前儿童邻面龋发病率的影响。117名4岁儿童被分为两组参与研究:(1)洗必泰凝胶组(n = 59),(2)安慰剂凝胶组(n = 58)。第1组每年用1%洗必泰凝胶治疗4次,第2组用安慰剂凝胶治疗。通过扁平牙线在牙间隙间涂抹约0.7毫升凝胶。研究还纳入了一个未接受任何牙线或凝胶治疗的对照组(第3组,n = 116)。3年后,即儿童7岁时,洗必泰凝胶组邻面龋(包括釉质和牙本质病变)的平均发病率为2.59,安慰剂凝胶组为4.53,对照组为4.20(第1组与第2组以及第1组与第3组比较:p < 0.01)。研究结束时,即儿童7岁时,洗必泰凝胶组邻面补牙的平均数量为0.33,安慰剂凝胶组为1.04,对照组为0.80(第1组与第2组比较:p < 0.01;第1组与第3组比较:p < 0.05)。从5岁到7岁通过咬合翼片X光片诊断的邻面龋损进展,洗必泰凝胶组比安慰剂凝胶组慢(对照组未在此方面进行评估)。基于总治疗时间(分钟)的成本分析显示,牙线清洁方案有小幅收益。(摘要截断于250字)