Gilabert J, Estellés A, Ayuso M J, España F, Chirivella M, Grancha S, Micó J M, Aznar J
Maternal Center, La Fe University Hospital, Valencia, Spain.
Gynecol Obstet Invest. 1994;38(3):157-62. doi: 10.1159/000292470.
Several fibrinolytic parameters were determined in plasma and amniotic fluid from normotensive pregnancies complicated by intrauterine fetal growth retardation (IUGR) and severe preeclamptic (PE) patients with IUGR and compared with data from normal pregnancies. A significant decrease in plasminogen activator type 2 (PAI-2) and urokinase levels in plasma and amniotic fluid was observed in IUGR groups in comparison with normal pregnancy. No significant differences were observed between the control and IUGR groups in relation to the other fibrinolytic parameters, except for plasma PAI type 1 and tissue-type plasminogen activator levels, which were significantly increased in the PE group. A significant positive correlation was observed between birth weight and PAI-2 levels in both plasma and amniotic fluid, but the plasma PAI-2 levels showed a higher correlation. In conclusion, these results suggest that the PAI-2 level measured in plasma is a more adequate marker of placental function than the PAI-2 level measured in amniotic fluid.
对患有宫内胎儿生长受限（IUGR）的血压正常孕妇以及患有IUGR的重度子痫前期（PE）患者的血浆和羊水进行了多项纤溶参数测定，并与正常妊娠的数据进行了比较。与正常妊娠相比，IUGR组血浆和羊水中的2型纤溶酶原激活物（PAI-2）和尿激酶水平显著降低。除了PE组血浆1型PAI和组织型纤溶酶原激活物水平显著升高外，对照组和IUGR组在其他纤溶参数方面未观察到显著差异。血浆和羊水中的出生体重与PAI-2水平之间均观察到显著正相关，但血浆PAI-2水平显示出更高的相关性。总之，这些结果表明，血浆中测得的PAI-2水平比羊水中测得的PAI-2水平更能充分反映胎盘功能。
