Karpati F, Malmborg A S, Alfredsson H, Hjelte L, Strandvik B
Dept. of Paediatrics, Karolinska Institutet, Huddinge Hospital, Sweden.
Infection. 1994 Jul-Aug;22(4):258-63. doi: 10.1007/BF01739911.
Xanthomonas maltophilia was isolated from 25 of 150 patients with cystic fibrosis during a period of 10 years (1983-1992). Twelve patients harboured X. maltophilia chronically, i.e. repeatedly for more than 6 months. No predisposing factors for the colonisation could be identified by studying the clinical and laboratory data of the patients, including preceding and concurrent bacterial colonisation with other bacteria, antibacterial treatments, pulmonary function and biochemical markers. Up to 2 years after the chronic colonisation was established no clinical deterioration could be verified, but the patients with X. maltophilia generally had a worse lung function at the latest follow-up (2-7 years after colonisation) than controls colonised with Pseudomonas aeruginosa (p < 0.05). Our data imply that X. maltophilia is a pathogen and the colonisation appears to follow the same pattern as the colonisation by P. aeruginosa. The development of resistance to different antibiotics, as revealed by analysis of the inhibition zones, was related to antibacterial treatment courses. X. maltophilia showed reduced sensitivity to the most commonly used antibiotics, ceftazidime and tobramycin.
在10年期间（1983 - 1992年），从150例囊性纤维化患者中的25例分离出嗜麦芽窄食单胞菌。12例患者长期携带嗜麦芽窄食单胞菌，即反复携带超过6个月。通过研究患者的临床和实验室数据，包括先前和同时存在的其他细菌的细菌定植、抗菌治疗、肺功能和生化指标，未发现该定植的诱发因素。在慢性定植确立后的2年内，未证实有临床恶化情况，但嗜麦芽窄食单胞菌感染的患者在最近一次随访（定植后2 - 7年）时的肺功能通常比铜绿假单胞菌感染的对照组更差（p < 0.05）。我们的数据表明嗜麦芽窄食单胞菌是一种病原体，其定植模式似乎与铜绿假单胞菌的定植模式相同。通过抑菌圈分析显示，对不同抗生素的耐药性发展与抗菌治疗疗程有关。嗜麦芽窄食单胞菌对最常用的抗生素头孢他啶和妥布霉素的敏感性降低。
