Dales R E, Raizenne M, el-Saadany S, Brook J, Burnett R
Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario.
Int J Epidemiol. 1994 Aug;23(4):775-81. doi: 10.1093/ije/23.4.775.
A large cross-sectional study provided an opportunity to estimate the prevalence of childhood asthma in several regions across Canada.
In 1988, approximately 18,000 questionnaires were distributed to the families of 5-8 year old children in 30 communities from the following six regions across Canada: the interior of British Columbia, southeastern Saskatchewan, southwestern Ontario, the central region of Ontario, southern Quebec, and the Maritimes (Nova Scotia and Prince Edward Island). These communities were free of point-source air pollutants and selected to represent a range of ambient sulphate concentrations. In all 14,948 questionnaires were returned representing an 83% response rate.
Currently present, physician-diagnosed asthma was reported for 4.7% of children by their parents. Persistent wheezing was reported for 13% and persistent cough for 5.9%. Asthma was most common in the two Maritime provinces (7.4%), and least common in British Columbia (3.3%) and Quebec (3.4%). Similar regional differences were seen for persistent cough, persistent wheeze, and also hospital separation rates for asthma which were approximately 800 per 100,000 for the Maritimes and 396 per 100,000 for British Columbia. Differences persisted despite adjustments for several host and environmental (indoor and outdoor) characteristics.
The east coast of Canada may be an endemic area of asthma in Canada. If confirmed by objective measures of asthma, a detailed aetiologic investigation could enhance understanding of this phenomenon and the major environmental determinants of asthma morbidity in general.
一项大型横断面研究提供了估计加拿大多个地区儿童哮喘患病率的机会。
1988年,向加拿大以下六个地区30个社区中5至8岁儿童的家庭发放了约18000份调查问卷:不列颠哥伦比亚省内陆地区、萨斯喀彻温省东南部、安大略省西南部、安大略省中部地区、魁北克省南部以及沿海省份(新斯科舍省和爱德华王子岛)。这些社区没有点源空气污染物,并且经过挑选以代表一系列环境硫酸盐浓度。共回收14948份调查问卷,回复率为83%。
父母报告目前有医生诊断为哮喘的儿童占4.7%。报告有持续性喘息的儿童占13%,有持续性咳嗽的儿童占5.9%。哮喘在两个沿海省份最为常见(7.4%),在不列颠哥伦比亚省(3.3%)和魁北克省(3.4%)最不常见。持续性咳嗽、持续性喘息以及哮喘的住院率也存在类似的地区差异,沿海省份约为每10万人800例,不列颠哥伦比亚省为每10万人396例。尽管对几个宿主和环境(室内和室外)特征进行了调整,差异仍然存在。
加拿大东海岸可能是加拿大哮喘的一个流行地区。如果通过哮喘的客观测量得到证实,详细的病因学调查可以增进对这一现象以及一般哮喘发病率的主要环境决定因素的理解。