Toki S, Ando K, Yoshida M, Matsuda Y
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co. Ltd., Japan.
J Antibiot (Tokyo). 1994 Nov;47(11):1175-81. doi: 10.7164/antibiotics.47.1175.
A novel compound, PS-990, which induces differentiation of neuroblastoma cells, was isolated from the culture broth of a fungus, Acremonium sp. KY12702. PS-990 inhibited brain calcium calmodulin-dependent cyclic nucleotide phosphodiesterase with an IC50 value of 3 micrograms/ml, and markedly induced neurite extension of mouse neuroblastoma, Neuro2A, at concentrations ranging from 10 to 30 micrograms ml.
