Nakanishi S, Ando K, Kawamoto I, Kase H
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
J Antibiot (Tokyo). 1989 Jul;42(7):1049-55. doi: 10.7164/antibiotics.42.1049.
New inhibitors of Ca2+ and calmodulin-dependent cyclic-nucleotide phosphodiesterase, KS-501 and KS-502 were isolated from a fungus, Sporothrix sp. KAC-1985. Inhibitory concentration causing 50% inhibition (IC50) values of KS-501 and KS-502 for bovine brain enzyme were 1.8 and 4.3 microM, respectively. The compounds exhibited no or weak inhibition for calmodulin-independent cyclic-nucleotide phosphodiesterases and protein kinase C.
从真菌Sporothrix sp. KAC - 1985中分离出新型钙和钙调蛋白依赖性环核苷酸磷酸二酯酶抑制剂KS - 501和KS - 502。KS - 501和KS - 502对牛脑酶的半数抑制浓度（IC50）值分别为1.8和4.3微摩尔。这些化合物对不依赖钙调蛋白的环核苷酸磷酸二酯酶和蛋白激酶C无抑制作用或抑制作用较弱。
