Susami E, Uchiyama K, Asanami S
Dept. of Dentistry and Oral Surgery, School of Medicine, Keio University.
Gan To Kagaku Ryoho. 1994 Jun;21(7):1063-6.
In 2 cases of squamous cell carcinoma of maxillary gingiva, carboplatin (CBDCA) was administered by continuous infusion for 5 days, and the clinical outcome and platinum concentrations in the peripheral blood, urine and tissue were investigated. Clinical effects were PR in one of the 2 cases and CR in the other. Platinum concentrations were as high as 3.17 and 13.90 micrograms/g in the tissue, but low in peripheral blood, not exceeding 0.61 and 0.62 micrograms/ml, respectively. These findings suggested that the present method secures the transport of the agent to a local site, with possible reduction of side effects.
在2例上颌牙龈鳞状细胞癌患者中，采用持续输注卡铂（CBDCA）5天的给药方式，并对临床疗效以及外周血、尿液和组织中的铂浓度进行了研究。2例患者中1例临床疗效为部分缓解（PR），另1例为完全缓解（CR）。组织中的铂浓度高达3.17和13.90微克/克，但外周血中的浓度较低，分别不超过0.61和0.62微克/毫升。这些结果表明，目前的方法可确保药物转运至局部部位，同时可能减少副作用。
