García-Martínez C, Llovera M, Agell N, López-Soriano F J, Argilés J M
Department de Biologia Cellular, Facultat de Medicina, Universitat de Barcelona, Spain.
Biochem Biophys Res Commun. 1994 Jun 15;201(2):682-6. doi: 10.1006/bbrc.1994.1754.
An acute intravenous administration of 100 micrograms/kg body weight of recombinant tumour necrosis factor-alpha resulted in a time-dependent increase in the levels of ubiquitin mRNAs in rat skeletal muscle. The results presented here, together with previous observations demonstrating that the cytokine increases the conjugation of proteins with ubiquitin in rat skeletal muscle (1), suggest that the ubiquitin system for non-lysosomal protein degradation could have a very important role in the mechanism triggered by tumour necrosis factor-alpha which is responsible for enhanced muscle proteolysis in sepsis and other pathological states.
以100微克/千克体重的剂量急性静脉注射重组肿瘤坏死因子-α，可使大鼠骨骼肌中泛素mRNA水平随时间增加。本文给出的结果，以及先前观察到的该细胞因子可增加大鼠骨骼肌中蛋白质与泛素的缀合作用（1），表明非溶酶体蛋白降解的泛素系统在由肿瘤坏死因子-α触发的机制中可能具有非常重要的作用，该机制导致脓毒症和其他病理状态下肌肉蛋白水解增强。
