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慢性阻塞性肺疾病中的肌肉减少症:机制、诊断及管理策略

Sarcopenia in chronic obstructive pulmonary disease: mechanisms, diagnosis, and management strategies.

作者信息

Khan Muhammad Hamza, Fatima Maham, Adnan Ahmad, Jawaid Alishba, Hassan Syed Muhammad, Talal Muhammad, Rahim Shazia, Mughal Zaib Un Nisa, Patel Aly Omer, Singh Achit Kumar

机构信息

Department of Medicine, Karachi Medical and Dental College, Karachi, Pakistan.

Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.

出版信息

Ann Med Surg (Lond). 2025 Jul 16;87(8):5106-5121. doi: 10.1097/MS9.0000000000003584. eCollection 2025 Aug.


DOI:10.1097/MS9.0000000000003584
PMID:40787546
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12333762/
Abstract

Sarcopenia affects 20%-40% of chronic obstructive pulmonary disease (COPD) patients, significantly reducing muscle strength and functional capacity, leading to a decline in quality of life. This study reviews the impact of sarcopenia in COPD and evaluates effective therapeutic strategies. Findings suggest that pulmonary rehabilitation, combined with aerobic and resistance exercises, and supplemented with protein and vitamin D, enhances muscle function and reduces the prevalence of sarcopenia. Additionally, emerging interventions such as inspiratory muscle training, myostatin inhibitors, selective androgen receptor modulators, and hormonal therapies show promise in improving patient outcomes. A multidisciplinary approach, incorporating personalized exercise programs, targeted nutrition, and psychological support, is crucial for addressing the complex challenges of sarcopenia in COPD. Given its substantial burden, this research highlights critical strategies for optimizing care and improving functional outcomes in this high-risk population.

摘要

肌肉减少症影响20%-40%的慢性阻塞性肺疾病(COPD)患者,显著降低肌肉力量和功能能力,导致生活质量下降。本研究回顾了肌肉减少症对慢性阻塞性肺疾病的影响,并评估了有效的治疗策略。研究结果表明,肺康复结合有氧运动和抗阻运动,并补充蛋白质和维生素D,可增强肌肉功能并降低肌肉减少症的患病率。此外,诸如吸气肌训练、肌肉生长抑制素抑制剂、选择性雄激素受体调节剂和激素疗法等新兴干预措施在改善患者预后方面显示出前景。采用多学科方法,纳入个性化运动计划、针对性营养和心理支持,对于应对慢性阻塞性肺疾病中肌肉减少症的复杂挑战至关重要。鉴于其巨大负担,本研究强调了优化护理和改善这一高危人群功能结局的关键策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/12333762/d7d11353990a/ms9-87-5106-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/12333762/72dc150772c0/ms9-87-5106-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/12333762/d7d11353990a/ms9-87-5106-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/12333762/72dc150772c0/ms9-87-5106-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/12333762/d7d11353990a/ms9-87-5106-g002.jpg

相似文献

[1]
Sarcopenia in chronic obstructive pulmonary disease: mechanisms, diagnosis, and management strategies.

Ann Med Surg (Lond). 2025-7-16

[2]
Pulmonary rehabilitation for chronic obstructive pulmonary disease.

Cochrane Database Syst Rev. 2015-2-23

[3]
Inspiratory muscle training, with or without concomitant pulmonary rehabilitation, for chronic obstructive pulmonary disease (COPD).

Cochrane Database Syst Rev. 2023-1-6

[4]
Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR).

J Nutr Health Aging. 2025-1

[5]
Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease.

Cochrane Database Syst Rev. 2016-12-8

[6]
The Role of Diaphragmatic Ultrasound in Identifying Sarcopenia in COPD Patients: A Cross-Sectional Study.

Int J Chron Obstruct Pulmon Dis. 2025-1-1

[7]
Computer and mobile technology interventions for self-management in chronic obstructive pulmonary disease.

Cochrane Database Syst Rev. 2017-5-23

[8]
WITHDRAWN: Interventions for fatigue and weight loss in adults with advanced progressive illness.

Cochrane Database Syst Rev. 2017-4-7

[9]
Interventions for fatigue and weight loss in adults with advanced progressive illness.

Cochrane Database Syst Rev. 2012-1-18

[10]
Supported self-management for patients with moderate to severe chronic obstructive pulmonary disease (COPD): an evidence synthesis and economic analysis.

Health Technol Assess. 2015-5

本文引用的文献

[1]
Emerging Targets and Treatments for Sarcopenia: A Narrative Review.

Nutrients. 2024-9-27

[2]
Risk Factors of Sarcopenia in COPD Patients: A Meta-Analysis.

Int J Chron Obstruct Pulmon Dis. 2024

[3]
Not Only Protein: Dietary Supplements to Optimize the Skeletal Muscle Growth Response to Resistance Training: The Current State of Knowledge.

J Hum Kinet. 2024-4-15

[4]
Chronic obstructive pulmonary disease as a risk factor for sarcopenia: A systematic review and meta-analysis.

PLoS One. 2024

[5]
Systematic review and meta-analysis of nutrient supplements for treating sarcopenia in people with chronic obstructive pulmonary disease.

Aging Clin Exp Res. 2024-3-14

[6]
The association between sarcopenia and incident of depressive symptoms: a prospective cohort study.

BMC Geriatr. 2024-1-18

[7]
Global Burden of Chronic Obstructive Pulmonary Disease Through 2050.

JAMA Netw Open. 2023-12-1

[8]
Multidisciplinary approach to sarcopenia: a narrative review.

J Yeungnam Med Sci. 2023-10

[9]
Association between chronic obstructive pulmonary disease and cardiovascular disease in adults aged 40 years and above: data from NHANES 2013-2018.

BMC Pulm Med. 2023-8-31

[10]
Long-Term Clinical Outcomes of Patients with Chronic Obstructive Pulmonary Disease with Sarcopenia.

Life (Basel). 2023-7-26

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