Kuwana M, Okano Y, Kaburaki J, Tojo T, Medsger T A
Keio University School of Medicine, Tokyo, Japan.
Arthritis Rheum. 1994 Jun;37(6):902-6. doi: 10.1002/art.1780370619.
To determine racial differences in the frequencies of systemic sclerosis (SSc)-related serum antinuclear antibodies (ANA).
We tested serum samples from 275 Japanese, 416 North American Caucasian, and 24 North American black SSc patients for 8 SSc-related serum ANA, using indirect immunofluorescence, double immunodiffusion, and radioimmunoprecipitation assays.
In comparing the 3 racial groups, we found that anti-U1 RNP, anti-RNA polymerase I, II, and III, and anti-U3 RNP antibodies were the most frequently detected antibodies in Japanese, Caucasian, and black patients, respectively. Anti-PM-Scl antibody was found exclusively in Caucasians.
The production of SSc-related serum ANA is related to immunogenetic background.
确定系统性硬化症（SSc）相关血清抗核抗体（ANA）频率的种族差异。
我们使用间接免疫荧光法、双向免疫扩散法和放射免疫沉淀法，对275名日本、416名北美白种人和24名北美黑人SSc患者的血清样本进行了8种SSc相关血清ANA检测。
在比较这3个种族群体时，我们发现抗U1 RNP、抗RNA聚合酶I、II和III以及抗U3 RNP抗体分别是日本、白种人和黑人患者中最常检测到的抗体。抗PM - Scl抗体仅在白种人中发现。
SSc相关血清ANA的产生与免疫遗传背景有关。
