Forman A D
Department of Neuro-Oncology, University of Texas, M.D. Anderson Cancer Center.
Oncology (Williston Park). 1994 Apr;8(4):105-10; discussion 113, 116-7.
There have been surprisingly few controlled studies of the central nervous system actions of cytokines in humans, although many clinical trials have briefly reported side effects of these drugs. Clinical trials using cytokines have chiefly involved patients with cancer, often at an advanced stage, and prospective formal neurologic assessment has been infrequent. In patients with malignancy, a host of variables can confound neurologic evaluation, including nutritional status, metastatic deposits, metabolic derangements, effects of former treatments, and infection. The effects of the cytokines on the central nervous system are multiple and limit their clinical use. Careful prospective clinical study of these agents is essential and may yield insights into their functions in the CNS and increase their efficacy as clinical tools.
尽管许多临床试验简要报告了这些药物的副作用，但令人惊讶的是，关于细胞因子对人类中枢神经系统作用的对照研究却很少。使用细胞因子的临床试验主要涉及癌症患者，而且往往是晚期患者，很少进行前瞻性的正式神经学评估。在恶性肿瘤患者中，许多变量会混淆神经学评估，包括营养状况、转移灶、代谢紊乱、既往治疗的影响以及感染。细胞因子对中枢神经系统的作用是多方面的，这限制了它们的临床应用。对这些药物进行仔细的前瞻性临床研究至关重要，可能会深入了解它们在中枢神经系统中的功能，并提高它们作为临床工具的疗效。
