Hibma M, Griffin J F
Department of Pathology, Cambridge University, United Kingdom.
Brain Behav Immun. 1994 Mar;8(1):80-5. doi: 10.1006/brbi.1994.1007.
The effect of maternal separation on in vivo and in vitro immune parameters was studied in young hybrid deer. Groups of fawns separated from their mothers either 2 days prior to or 7 days post immunization with keyhole limpet hemocyanin were compared with a control group of immunized, unseparated fawns. Animals separated prior to antigenic challenge had significantly higher concentrations of antigen-specific IgG in their serum than control animals. There was no influence on the humoral immune response in animals separated following immunization. In contrast, Con A transformations were transiently depressed in separated animals compared to the control group. The time separation was imposed relative to challenge and therefore influenced the subsequent immune response.
在幼年杂交鹿中研究了母婴分离对体内和体外免疫参数的影响。将在免疫匙孔血蓝蛋白前2天或免疫后7天与其母亲分离的幼鹿组与未分离的免疫幼鹿对照组进行比较。在抗原攻击前分离的动物血清中抗原特异性IgG浓度明显高于对照动物。免疫后分离的动物的体液免疫反应没有受到影响。相比之下，与对照组相比，分离动物的Con A转化反应暂时受到抑制。分离时间是相对于攻击而言的，因此影响了随后的免疫反应。
