洛沙平与三氟拉嗪治疗急慢性精神分裂症患者的双盲对照试验。

A double-blind comparative trial of loxapine and trifluoperazine in acute and chronic schizophrenic patients.

作者信息

Kiloh L G, Williams S E, Grant D A, Whetton P S

出版信息

J Int Med Res. 1976;4(6):441-8. doi: 10.1177/030006057600400611.

Abstract

A double-blind comparative trial of loxapine and trifluoperazine was carried out in 57 acute and chronic schizophrenic patients. In both groups of patients loxapine proved to be equivalent in its effects to trifluoperazine and there were suggestions it might be rather more effective in chronic patients. Side-effects were similar with the two drugs but anticholinergic effects, excitement, dizziness and faintness occurred rather more commonly with loxapine. Laboratory tests, urine analysis, cardiovascular and ophthalmological investigations showed no significant abnormalities.

摘要

对57名急慢性精神分裂症患者进行了洛沙平与三氟拉嗪的双盲对照试验。在两组患者中，洛沙平的疗效被证明与三氟拉嗪相当，且有迹象表明它对慢性患者可能更有效。两种药物的副作用相似，但洛沙平的抗胆碱能作用、兴奋、头晕和昏厥更为常见。实验室检查、尿液分析、心血管和眼科检查均未显示明显异常。