蛋白质折叠动力学：扩散-碰撞模型与实验数据
Protein folding dynamics: the diffusion-collision model and experimental data.
作者信息
Karplus M, Weaver D L
机构信息
Department of Chemistry, Harvard University, Cambridge, Massachusetts 02138.
出版信息
Protein Sci. 1994 Apr;3(4):650-68. doi: 10.1002/pro.5560030413.
Abstract
The diffusion-collision model of protein folding is assessed. A description is given of the qualitative aspects and quantitative results of the diffusion-collision model and their relation to available experimental data. We consider alternative mechanisms for folding and point out their relationship to the diffusion-collision model. We show that the diffusion-collision model is supported by a growing body of experimental and theoretical evidence, and we outline future directions for developing the model and its applications.
摘要
对蛋白质折叠的扩散-碰撞模型进行了评估。文中描述了扩散-碰撞模型的定性方面、定量结果及其与现有实验数据的关系。我们考虑了折叠的替代机制，并指出了它们与扩散-碰撞模型的关系。我们表明，越来越多的实验和理论证据支持扩散-碰撞模型，并且概述了该模型及其应用的未来发展方向。
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