Tribe R M, Barton J R, Poston L, Burney P G
Department of Public Health Medicine and Renal Laboratory, United Medical School, Guy's Hospital, London, United Kingdom.
Am J Respir Crit Care Med. 1994 Jun;149(6):1426-33. doi: 10.1164/ajrccm.149.6.8004294.
Both epidemiologic and experimental evidence suggest that a high dietary sodium intake may increase airway responsiveness, but no adequate explanation exists of how changes in sodium intake might lead to increased responsiveness. This investigation was carried out to study dietary sodium intake and airway response to methacholine in relation to cellular sodium transport in 52 young men. Airway response to methacholine was associated with urinary sodium excretion when subjects were on normal sodium intake. Airway responsiveness in patients with mild asthma correlated with the furosemide-insensitive influx of sodium into peripheral leukocytes stimulated by autologous serum, but there was no relation between this influx and 24-h urinary sodium excretion. In a separate investigation, serum from subjects with increased airway responsiveness caused an increase in the sodium influx and sodium content of leukocytes from nonatopic subjects. The magnitude of the furosemide-insensitive, serum stimulated influx was related to the degree of airway responsiveness of the serum donor, as was the increase in intracellular sodium content. Neither was related to the 24-h urinary sodium excretion of the donor. Patients with airway hyperresponsiveness have an increased sodium influx into cells stimulated by a serum-borne factor. This is independent of the effect of added dietary sodium on airway responsiveness.
流行病学和实验证据均表明，高膳食钠摄入量可能会增加气道反应性，但对于钠摄入量的变化如何导致反应性增加，目前尚无充分解释。本研究旨在探讨52名年轻男性的膳食钠摄入量、对乙酰甲胆碱的气道反应与细胞钠转运之间的关系。当受试者摄入正常钠量时，对乙酰甲胆碱的气道反应与尿钠排泄相关。轻度哮喘患者的气道反应性与速尿不敏感的钠流入外周白细胞相关，该钠流入由自体血清刺激引起，但此流入与24小时尿钠排泄之间无关联。在另一项研究中，气道反应性增加的受试者的血清导致非特应性受试者白细胞的钠流入和钠含量增加。速尿不敏感的、血清刺激的钠流入量与血清供体的气道反应程度相关，细胞内钠含量的增加也与之相关。两者均与供体的24小时尿钠排泄无关。气道高反应性患者受血清源性因子刺激后，细胞内钠流入增加。这与膳食中添加钠对气道反应性的影响无关。
