经皮气囊瓣膜成形术治疗新生儿先天性重度肺动脉狭窄

Percutaneous balloon valvuloplasty for congenital critical pulmonary stenosis in neonates.

作者信息

Hwang B, Lu J H, Meng C C

机构信息

Department of Pediatrics, Veterans General Hospital-Taipei, Taiwan, R.O.C.

出版信息

Zhonghua Yi Xue Za Zhi (Taipei). 1994 Apr;53(4):228-32.

PMID:8004529

Abstract

BACKGROUND

Percutaneous balloon valvuloplasty (PBVP) was performed on 6 neonates with severe pulmonary stenosis to evaluate its efficacy.

METHODS

The 6 studied neonates were aged from 1 to 30 days and weighed 2.5 to 3.3 kg. Follow-up period ranged 6-21 months with a mean of 11.5 +/- 6.3 months.

RESULTS

Dramatic improvement after PBVP was obtained not only on the clinical manifestations but also on the hemodynamic data. After percutaneous balloon valvuloplasty, the aortic O2 saturation increased significantly from 71.3 +/- 14.8% to 83.2 +/- 9.3% (p = 0.001) in 5 neonates who had cyanosis before PBVP. The right to left ventricular peak systolic pressure ratio decreased significantly from 1.65 +/- 0.41 to 0.77 +/- 0.27 (p < 0.001). The peak systolic right ventricular pressure dropped significantly from 104.0 +/- 18.8 to 48.8 +/- 13.6 mmHg (p < 0.001). The peak systolic gradient between right ventricle and main pulmonary artery dropped significantly from 83.2 +/- 16.2 to 24.3 +/- 16.3 mmHg (p < 0.05).

CONCLUSIONS

The percutaneous balloon valvuloplasty is safe and effective in treating the neonates with congenital critical pulmonary stenosis.

摘要

背景

对6例患有严重肺动脉狭窄的新生儿进行经皮球囊瓣膜成形术（PBVP）以评估其疗效。

方法

6例研究对象为1至30日龄的新生儿，体重2.5至3.3千克。随访期为6至21个月，平均为11.5±6.3个月。

结果

经皮球囊瓣膜成形术后不仅临床表现显著改善，血流动力学数据也显著改善。在术前有紫绀的5例新生儿中，经皮球囊瓣膜成形术后，主动脉血氧饱和度从71.3±14.8%显著升至83.2±9.3%（p = 0.001）。右心室与左心室收缩压峰值比从1.65±0.41显著降至0.77±0.27（p < 0.001）。右心室收缩压峰值从104.0±18.8显著降至48.8±13.6 mmHg（p < 0.001）。右心室与主肺动脉之间的收缩压峰值梯度从83.2±16.2显著降至24.3±16.3 mmHg（p < 0.05）。