Hwang B, Lu J H, Meng C C
Department of Pediatrics, Veterans General Hospital-Taipei, Taiwan, R.O.C.
Zhonghua Yi Xue Za Zhi (Taipei). 1994 Apr;53(4):228-32.
Percutaneous balloon valvuloplasty (PBVP) was performed on 6 neonates with severe pulmonary stenosis to evaluate its efficacy.
The 6 studied neonates were aged from 1 to 30 days and weighed 2.5 to 3.3 kg. Follow-up period ranged 6-21 months with a mean of 11.5 +/- 6.3 months.
Dramatic improvement after PBVP was obtained not only on the clinical manifestations but also on the hemodynamic data. After percutaneous balloon valvuloplasty, the aortic O2 saturation increased significantly from 71.3 +/- 14.8% to 83.2 +/- 9.3% (p = 0.001) in 5 neonates who had cyanosis before PBVP. The right to left ventricular peak systolic pressure ratio decreased significantly from 1.65 +/- 0.41 to 0.77 +/- 0.27 (p < 0.001). The peak systolic right ventricular pressure dropped significantly from 104.0 +/- 18.8 to 48.8 +/- 13.6 mmHg (p < 0.001). The peak systolic gradient between right ventricle and main pulmonary artery dropped significantly from 83.2 +/- 16.2 to 24.3 +/- 16.3 mmHg (p < 0.05).
The percutaneous balloon valvuloplasty is safe and effective in treating the neonates with congenital critical pulmonary stenosis.
对6例患有严重肺动脉狭窄的新生儿进行经皮球囊瓣膜成形术（PBVP）以评估其疗效。
6例研究对象为1至30日龄的新生儿，体重2.5至3.3千克。随访期为6至21个月，平均为11.5±6.3个月。
经皮球囊瓣膜成形术后不仅临床表现显著改善，血流动力学数据也显著改善。在术前有紫绀的5例新生儿中，经皮球囊瓣膜成形术后，主动脉血氧饱和度从71.3±14.8%显著升至83.2±9.3%（p = 0.001）。右心室与左心室收缩压峰值比从1.65±0.41显著降至0.77±0.27（p < 0.001）。右心室收缩压峰值从104.0±18.8显著降至48.8±13.6 mmHg（p < 0.001）。右心室与主肺动脉之间的收缩压峰值梯度从83.2±16.2显著降至24.3±16.3 mmHg（p < 0.05）。
经皮球囊瓣膜成形术治疗先天性严重肺动脉狭窄新生儿安全有效。
