丝裂霉素C、维拉帕米和热疗对人胃腺癌的影响。
Effect of mitomycin C, verapamil, and hyperthermia on human gastric adenocarcinoma.
作者信息
Shchepotin I B, Buras R R, Nauta R J, Shabahang M, Evans S R
机构信息
Department of Surgery, Georgetown University, Washington, D.C.
出版信息
Cancer Chemother Pharmacol. 1994;34(3):257-60. doi: 10.1007/BF00685086.
The purpose of this study was to assess the efficacy of verapamil (20 microM) and hyperthermia (42 degrees C) as modifiers of mitomycin C (MMC), used at different concentrations, in inhibiting the growth of human gastric adenocarcinoma (AGS) cells. Combined verapamil and hyperthermia treatment resulted in a significant decrease in cell count by 72.2% as compared with the control value. Verapamil drastically enhanced the growth-inhibitory activity of MMC at high concentration against AGS cells by 67.5% and had no effect at intermediate and low concentrations. Hyperthermia did not enhance the effect of MMC on AGS cells. The modalities analyzed in this study require further investigation and may have potential for in vivo studies on gastric cancer therapy in the near future.
本研究的目的是评估维拉帕米（20微摩尔）和热疗（42摄氏度）作为丝裂霉素C（MMC）不同浓度时的调节剂，对抑制人胃腺癌（AGS）细胞生长的效果。与对照值相比，维拉帕米和热疗联合治疗使细胞计数显著减少了72.2%。维拉帕米在高浓度时能显著增强MMC对AGS细胞的生长抑制活性，提高了67.5%，而在中低浓度时无作用。热疗并未增强MMC对AGS细胞的作用。本研究中分析的这些方式需要进一步研究，并且在不久的将来可能有用于胃癌治疗体内研究的潜力。
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