Reed T, Tracy R P, Fabsitz R R
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis.
Clin Genet. 1994 Feb;45(2):71-7. doi: 10.1111/j.1399-0004.1994.tb03997.x.
Plasma fibrinogen was determined in 189 twins participating at the Indiana center during the third examination of the NHLBI twin study with a mean age of 63 years. Moderate heritability estimates were obtained from 44 complete MZ pairs and 39 complete DZ pairs. After adjustment of fibrinogen levels for age and other confounding variables related to cardiovascular disease risk, the maximum likelihood heritability estimate was only 30% (p = 0.03). Plasma fibrinogen was most strongly associated with smoking and the presence of diabetes. Omitting all subjects with diabetes or cardiovascular disease further reduced the heritability estimates slightly, and most path models including genetic parameters provided no significant improvement in fit over a model determined solely by random environmental effects. Our results are consistent with the environment rather than genetic influences having a greater influence on the level of plasma fibrinogen.
在国家心肺血液研究所双胞胎研究的第三次检查中，对印第安纳中心参与研究的189对双胞胎进行了血浆纤维蛋白原测定，这些双胞胎的平均年龄为63岁。从44对完全相同的同卵双胞胎（MZ）和39对完全相同的异卵双胞胎（DZ）中获得了中度遗传度估计值。在对纤维蛋白原水平进行年龄和其他与心血管疾病风险相关的混杂变量调整后，最大似然遗传度估计值仅为30%（p = 0.03）。血浆纤维蛋白原与吸烟和糖尿病的存在关联最为密切。剔除所有患有糖尿病或心血管疾病的受试者后，遗传度估计值略有进一步降低，并且大多数包含遗传参数的路径模型与仅由随机环境效应决定的模型相比，在拟合度上没有显著改善。我们的结果表明，环境而非遗传因素对血浆纤维蛋白原水平的影响更大。
