Conti C R
Clin Cardiol. 1994 May;17(5):227-8. doi: 10.1002/clc.4960170502.
The vasorelaxant property of inhaled nitric oxide is rapidly lost because it binds to hemoglobin. Its selective action in the pulmonary circulation and bronchial smooth muscle has the advantage of not decreasing systemic vascular resistance with resultant systemic hypotension. In the adult population, patients with ARDS, COLD, asthma, and increased pulmonary vascular resistance postoperatively are likely to benefit from inhaled nitric oxide, at least transiently. However, before inhaled nitric oxide can be recommended for routine use, further study of the potential adverse effects needs to be carried out.
吸入一氧化氮的血管舒张特性会迅速丧失，因为它会与血红蛋白结合。其在肺循环和支气管平滑肌中的选择性作用具有不降低体循环血管阻力及由此导致的系统性低血压的优势。在成年人群中，患有急性呼吸窘迫综合征（ARDS）、慢性阻塞性肺疾病（COLD）、哮喘以及术后肺血管阻力增加的患者可能至少会暂时从吸入一氧化氮中获益。然而，在推荐将吸入一氧化氮用于常规治疗之前，需要对其潜在的不良反应进行进一步研究。
