Fujii K, Ozaki M, Yamagishi T, Ishine K, Furutani Y, Nagano H, Yamamoto K, Saiki A, Matsuzaki M
Second Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Japan.
Clin Cardiol. 1994 May;17(5):258-62. doi: 10.1002/clc.4960170508.
Many invasive and noninvasive methods have been used to study the cardiac atria; however, few allow quantitative measurement of atrial function. To determine the interaction between left ventricular (LV) contraction and left atrial (LA) filling, gated radionuclide angiography was conducted in 30 normal subjects (24 men and 6 women, mean age 58 +/- 10 years, range 26-68). LV and LA time-activity curves and their first-derivative curves were obtained simultaneously by using the method of Bough et al. The LV ejection fraction (64 +/- 18%) and LV peak ejection rate (LVPER; 3.42 +/- 0.27 EDV/s) were computed from these curves. As indices of LA filling, LA fractional emptying (38 +/- 12%) and LA peak filling rate (LAPFR; 2.86 +/- 0.17 LAVmax/s)--the latter being defined as the peak rate of LA filling during the LA filling phase--were also computed from these curves. In all subjects, the timing of the LVPER coincided with the occurrence of LAPFR, and there was a significant positive correlation between the LVPER and LAPFR (r = 0.81, p < 0.001), indicating that the LAPFR was strongly affected by the degree of LVPER. Thus, these results indicate that LV contractile performance plays an important role in determining LA passive filling during ventricular systole.
许多侵入性和非侵入性方法已被用于研究心脏心房；然而，很少有方法能够对心房功能进行定量测量。为了确定左心室（LV）收缩与左心房（LA）充盈之间的相互作用，对30名正常受试者（24名男性和6名女性，平均年龄58±10岁，范围26 - 68岁）进行了门控放射性核素血管造影。通过使用Bough等人的方法同时获得左心室和左心房的时间 - 活性曲线及其一阶导数曲线。从这些曲线计算出左心室射血分数（64±18%）和左心室峰值射血率（LVPER；3.42±0.27 EDV/s）。作为左心房充盈的指标，左心房分数排空率（38±12%）和左心房峰值充盈率（LAPFR；2.86±0.17 LAVmax/s）——后者定义为左心房充盈期左心房充盈的峰值速率——也从这些曲线计算得出。在所有受试者中，左心室峰值射血率的时间与左心房峰值充盈率的出现时间一致，并且左心室峰值射血率与左心房峰值充盈率之间存在显著正相关（r = 0.81，p < 0.001），表明左心房峰值充盈率受左心室峰值射血率程度的强烈影响。因此，这些结果表明左心室收缩性能在心室收缩期确定左心房被动充盈中起重要作用。
