Shih W J, Dillon M L
Nuclear Medicine Service, Veterans Affairs Medical Center, Lexington, Kentucky 40511.
Clin Nucl Med. 1994 Apr;19(4):279-86. doi: 10.1097/00003072-199404000-00001.
Airway occlusion results in regional alveolar hypoxia followed by reflex hypoxic pulmonary arterial constriction. Ventilation-perfusion imaging demonstrates matched defects. In the two patients reported, occlusion of the main bronchus by bronchogenic carcinoma was resolved--in one case by radiation therapy, and in the other by removal of the tumor mass in the bronchus by bronchial slitted biopsy. The initially matched ventilation-perfusion findings became mismatched. While ventilation was presumed to be normal, pulmonary perfusion was not completely reversed.
气道阻塞导致局部肺泡缺氧，继而引发反射性低氧性肺动脉收缩。通气-灌注显像显示匹配性缺损。在报道的2例患者中，支气管肺癌导致的主支气管阻塞得到了解决——1例通过放射治疗，另1例通过支气管切开活检切除支气管内的肿瘤块。最初匹配的通气-灌注表现变得不匹配。虽然推测通气正常，但肺灌注并未完全恢复。
