Joffe M, Li Z
Academic Department of Public Health, St. Mary's Hospital Medical School, London, United Kingdom.
Fertil Steril. 1994 Jul;62(1):71-5. doi: 10.1016/s0015-0282(16)56818-6.
To examine the relationship of subfertility with miscarriage, low birth weight, and preterm delivery.
Comparison of time to pregnancy distributions between pregnancies that had different outcomes. Three comparisons were made: (a) miscarriages with live births; within live births, (b) low birth weight infant (up to 2,500 grams) or not low birth weight; (c) preterm birth (37 weeks or less) or not preterm. Cox regression was used to adjust for covariates.
All first pregnancies were analyzed from the National Child Development Study, a large survey of young adults aged 33 years, which is nationally representative of the British-born population.
The distribution of the time taken to conceive (time to pregnancy), miscarriage, birth weight, and preterm delivery.
Pregnancies that ended in miscarriage tended to take 23% longer to conceive, after adjustment for the other variables. Pregnancies that resulted in preterm delivery tended to take 15% longer to conceive. There was no statistically significant association with low birth weight.
Delay in time to conception is a risk factor for poor obstetric outcome, irrespective of medical intervention.
探讨亚生育力与流产、低出生体重和早产之间的关系。
比较不同妊娠结局的妊娠受孕时间分布。进行了三项比较：（a）流产与活产；在活产中，（b）低出生体重儿（体重达2500克）与非低出生体重儿；（c）早产（37周及以下）与非早产。采用Cox回归对协变量进行调整。
对全国儿童发展研究中的所有首次妊娠进行分析，该研究是对33岁年轻人的一项大型调查，对英国出生人口具有全国代表性。
受孕时间（妊娠时间）、流产、出生体重和早产的分布情况。
在对其他变量进行调整后，以流产告终的妊娠受孕时间往往要长23%。导致早产的妊娠受孕时间往往要长15%。与低出生体重无统计学上的显著关联。
无论是否进行医学干预，受孕时间延迟都是不良产科结局的一个危险因素。
