鸡胚中枢神经系统中的肉碱及其衍生物

Carnitine and derivatives in the central nervous system of chick embryo.

Chiodi P, Ciani B, Kentroti S, Maccari F, Vernadakis A, Angelucci L, Ramacci M T

Institute for Research on Senescence, Sigma Tau S.p.A., Pomezia, Rome, Italy.

Int J Biochem. 1994 May;26(5):711-20. doi: 10.1016/0020-711x(94)90171-6.

Abstract

Carnitine contents and the activity of carnitine acetyltransferase in the egg, in the embryo, and in different brain areas of central nervous system in chick embryo were determined in the course of development. 2. The egg showed low levels of free carnitine and acetylcarnitine. 3. In the whole embryo, at first stages of development, long chain acylcarnitine and acetylcarnitine were the best represented classes of carnitines. 4. In the brain regions acetylcarnitine levels, high at the first days, showed a continual decrease during development. 5. The activity of carnitine acetyltransferase increased and was totally related to development.

摘要

在鸡胚发育过程中，测定了鸡蛋、胚胎以及中枢神经系统不同脑区中肉碱的含量和肉碱乙酰转移酶的活性。2. 鸡蛋中游离肉碱和乙酰肉碱的水平较低。3. 在整个胚胎发育的最初阶段，长链酰基肉碱和乙酰肉碱是肉碱中含量最丰富的类别。4. 在脑区，乙酰肉碱水平在最初几天较高，在发育过程中持续下降。5. 肉碱乙酰转移酶的活性增加，且与发育完全相关。