Costell M, O'Connor J E, Grisolía S
Instituto de Investigaciones Citológicas, de la Caja de Ahorros de Valencia, Spain.
Biochem Biophys Res Commun. 1989 Jun 30;161(3):1135-43. doi: 10.1016/0006-291x(89)91360-0.
Carnitine deficiency associated with impairment of muscle function has been described in infants and young adults as a result of inherited or acquired disease but there are no reports on carnitine levels in healthy aging people. In this paper we show a marked reduction of carnitine and its derivatives in muscle, and of long-chain acyl carnitine in heart of 6-month-old mice, when compared to animals of 6 weeks of age. Analysis of muscle samples of healthy humans of different ages showed a drastic reduction of carnitine and acetyl carnitine in the older subjects with a strong reverse correlation between age and carnitine levels.
由于遗传或后天疾病，婴儿和年轻人中已出现与肌肉功能受损相关的肉碱缺乏症，但尚无关于健康老年人肉碱水平的报道。在本文中，我们发现与6周龄的小鼠相比，6月龄小鼠肌肉中的肉碱及其衍生物以及心脏中的长链酰基肉碱显著减少。对不同年龄健康人的肌肉样本分析表明，老年受试者的肉碱和乙酰肉碱大幅减少，年龄与肉碱水平之间存在强烈的负相关。
