Vadillo Ortega F, Beltrán J, Mateo H, Monzón F
Instituto Nacional de Perinatología, México, D.F.
Ginecol Obstet Mex. 1994 May;62:143-5.
The phospholipase A2 activity in young amniotic fluids: 1.782, was determined. In the term amniotic fluids, the activity was 10.693. The detected activity in fluids from premature rupture of membranes was 29.077 in the group with infection, add 12.357 for the samples without infection. It was seen that young amniotic fluid has less activity. The group with infection showed the greatest activity. The significant increase of phospholipase A2 activity in term amniotic fluids and with PRM, in comparison with what is seen in young fluids suggests the active participation of the soluble form of this enzyme as mediator in the increase of Prostaglandin E2 seen in the amniotic fluid of the two first groups. Accordingly, one may think that PPLA2 could be a central mediator in membranes rupture mechanism in normal labor, as in PRM.
测定了年轻羊水样本中磷脂酶A2的活性为1.782。足月羊水样本中该活性为10.693。胎膜早破样本中，感染组检测到的活性为29.077，未感染样本的活性为12.357。可见年轻羊水的活性较低。感染组的活性最高。与年轻羊水相比，足月羊水和胎膜早破样本中磷脂酶A2活性显著增加，这表明该酶的可溶性形式作为介质，积极参与了前两组羊水中前列腺素E2的增加。因此，可以认为磷脂酶A2可能是正常分娩和胎膜早破时胎膜破裂机制的核心介质。
