常染色体隐性多囊肾病并不定位于4号染色体上常染色体显性多囊肾病的第二个基因位点。
Autosomal recessive polycystic kidney disease does not map to the second gene locus for autosomal dominant polycystic kidney disease on chromosome 4.
作者信息
Zerres K, Mücher G, Rudnik-Schöneborn S
机构信息
Institut für Humangenetik, Universität Bonn, Germany.
出版信息
Hum Genet. 1994 Jun;93(6):697-8. doi: 10.1007/BF00201574.
PMID:8005596
Abstract
Linkage analysis in 19 families with autosomal recessive polycystic kidney disease (ARPKD) has shown that ARPKD is not linked to the recently assigned second gene locus for autosomal dominant polycystic kidney disease (ADPKD) on chromosome 4q (PKD2). Thus, there is strong evidence that ADPKD and ARPKD have different gene loci.
摘要
对19个常染色体隐性多囊肾病（ARPKD）家族进行的连锁分析表明，ARPKD与最近确定位于4号染色体q臂上的常染色体显性多囊肾病（ADPKD）的第二个基因位点（PKD2）不连锁。因此，有充分证据表明ADPKD和ARPKD具有不同的基因位点。
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