常染色体隐性和显性形式的多囊肾病并非等位基因。
Autosomal recessive and dominant forms of polycystic kidney disease are not allelic.
作者信息
Wirth B, Zerres K, Fischbach M, Claus D, Neumann H P, Lennert T, Brodehl J, Neugebauer M, Müller-Wiefel D E, Geisert J
机构信息
Institut für Humangenetik der Universität, Bonn, Federal Republic of Germany.
出版信息
Hum Genet. 1987 Nov;77(3):221-2. doi: 10.1007/BF00284473.
Linkage analysis has been carried out in 11 kindreds with autosomal recessive polycystic kidney disease (ARPKD) using the genetic marker 3'HVR, closely linked (theta = 0.05) to the gene of the autosomal dominant type. Close linkage (theta less than or equal to 0.20) between the locus of the marker and that of ARPKD can be excluded. These data strongly suggest that the loci for the autosomal recessive and dominant forms of polycystic kidney disease are not allelic.
利用与常染色体显性型基因紧密连锁（θ = 0.05）的遗传标记3'HVR，对11个常染色体隐性多囊肾病（ARPKD）家系进行了连锁分析。标记位点与ARPKD位点之间紧密连锁（θ≤0.20）可以排除。这些数据有力地表明，常染色体隐性和显性形式的多囊肾病基因座不是等位基因。
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