CD4+ CD8- NK1.1+胸腺细胞发育的I类依赖性。
Class I dependence of the development of CD4+ CD8- NK1.1+ thymocytes.
作者信息
Coles M C, Raulet D H
机构信息
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
出版信息
J Exp Med. 1994 Jul 1;180(1):395-9. doi: 10.1084/jem.180.1.395.
Abstract
A small subset of functionally active CD4+ CD8- thymocytes express the NK1.1 marker, as do most CD4-CD8- NK1.1+ thymocytes. Previous studies have failed to implicate a role for major histocompatibility complex (MHC) or related molecules in the selection of the CD4+ CD8- NK1.1+ subset. We report here that the development of most of these cells is sharply reduced in class I-deficient mice, but not in class II-deficient mice. Hence, some CD4+ T cells are class I dependent and not class II dependent. Unlike conventional T cells, however, the development of NK1.1+ thymocytes in both the CD4+ CD8- and CD4- CD8- subsets is dependent on class I MHC expression by hematopoietic cells and not thymic epithelial cells. We propose that these populations are selected by nonpolymorphic class Ib or CD1 molecules.
摘要
一小部分功能活跃的CD4+ CD8-胸腺细胞表达NK1.1标志物，大多数CD4- CD8- NK1.1+胸腺细胞也是如此。先前的研究未能表明主要组织相容性复合体（MHC）或相关分子在CD4+ CD8- NK1.1+亚群的选择中发挥作用。我们在此报告，在I类缺陷小鼠中，这些细胞中的大多数发育急剧减少，但在II类缺陷小鼠中则不然。因此，一些CD4+ T细胞依赖I类而不依赖II类。然而，与传统T细胞不同，CD4+ CD8-和CD4- CD8-亚群中NK1.1+胸腺细胞的发育依赖于造血细胞而非胸腺上皮细胞表达的I类MHC。我们提出，这些群体是由非多态性的Ib类或CD1分子选择的。
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