造血细胞表达的I类分子对Vβ8 + CD4 - 8 - 胸腺细胞的阳性选择。
Positive selection of V beta 8+ CD4-8- thymocytes by class I molecules expressed by hematopoietic cells.
作者信息
Bix M, Coles M, Raulet D
机构信息
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
出版信息
J Exp Med. 1993 Sep 1;178(3):901-8. doi: 10.1084/jem.178.3.901.
Abstract
A small subset of T cells of mature phenotype express the alpha/beta T cell receptor, but not CD4 and CD8 coreceptors (alpha/beta double-negative [DN] cells). The repertoire of V beta usage of alpha/beta DN cells is strongly biased towards V beta 8 expression, suggesting that the formation of the population is subject to selection. We now report that deficiency of class I expression leads to a strongly depressed frequency of V beta 8+ DN cells, but has little effect on V beta 8- DN cells. Studies of hematopoietic chimeras between class I+ and class I- mice demonstrated that expression of class I molecules by hematopoietic cells is necessary and sufficient for selection of most V beta 8 DN cells. The lack of a role for class I expression by thymic epithelial cells suggests that the mechanism of selection of these cells by class I differs significantly from the mechanism of selection of conventional T cells. Models to explain the selection of these cells as well as their possible function in vivo are discussed.
摘要
一小部分具有成熟表型的T细胞表达α/β T细胞受体，但不表达CD4和CD8共受体（α/β双阴性[DN]细胞）。α/β DN细胞的Vβ使用谱强烈偏向于Vβ8表达，这表明该群体的形成受到选择作用。我们现在报告，I类分子表达缺陷导致Vβ8 + DN细胞频率大幅降低，但对Vβ8 - DN细胞影响很小。对I类和I类小鼠之间造血嵌合体的研究表明，造血细胞表达I类分子对于大多数Vβ8 DN细胞的选择是必要且充分的。胸腺上皮细胞表达I类分子缺乏作用，这表明I类分子对这些细胞的选择机制与传统T细胞的选择机制有显著差异。文中讨论了解释这些细胞选择的模型以及它们在体内可能的功能。
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本文引用的文献
1
Developmentally regulated expression of T cell receptor beta chain variable domains in immature thymocytes.未成熟胸腺细胞中T细胞受体β链可变区的发育调控表达。
J Exp Med. 1987 Aug 1;166(2):577-82. doi: 10.1084/jem.166.2.577.
2
T cell tolerance by clonal elimination in the thymus.胸腺中通过克隆清除实现的T细胞耐受性。
Cell. 1987 Apr 24;49(2):273-80. doi: 10.1016/0092-8674(87)90568-x.
3
Deletion of potentially self-reactive T cell receptor specificities in L3T4-, Lyt-2- T cells of lpr mice.lpr小鼠L3T4-、Lyt-2-T细胞中潜在自身反应性T细胞受体特异性的缺失。
J Exp Med. 1988 Dec 1;168(6):2221-9. doi: 10.1084/jem.168.6.2221.
4
Positive selection of CD4+ thymocytes controlled by MHC class II gene products.由MHC II类基因产物控制的CD4+胸腺细胞的阳性选择。
Nature. 1988 Dec 1;336(6198):471-3. doi: 10.1038/336471a0.
5
The effect of thymus environment on T cell development and tolerance.胸腺环境对T细胞发育及耐受性的影响。
Cell. 1988 May 20;53(4):627-34. doi: 10.1016/0092-8674(88)90578-8.
6
Phenotypic properties, interleukin 2 production, and developmental origin of a "mature" subpopulation of Lyt-2- L3T4- mouse thymocytes.Lyt-2-L3T4-小鼠胸腺细胞“成熟”亚群的表型特性、白细胞介素2产生及发育起源
Proc Natl Acad Sci U S A. 1987 Dec;84(23):8578-82. doi: 10.1073/pnas.84.23.8578.
7
A novel population of T-cell receptor alpha beta-bearing thymocytes which predominantly expresses a single V beta gene family.一种新的携带αβ型T细胞受体的胸腺细胞群体，其主要表达单个Vβ基因家族。
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8
T-cell lineages, repertoire selection and tolerance induction.T细胞谱系、 repertoire选择与耐受性诱导
Immunol Rev. 1988 Aug;104:157-82. doi: 10.1111/j.1600-065x.1988.tb00762.x.
9
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10
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Nature. 1986;321(6067):219-26. doi: 10.1038/321219a0.
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