Arshinoff S, D'Addario D, Sadler C, Bilotta R, Johnson T M
J Cataract Refract Surg. 1994 Mar;20 Suppl:216-22. doi: 10.1016/s0886-3350(13)80756-0.
Nonsteroidal anti-inflammatory drugs (NSAIDs) produce potent analgesic, antipyretic, and anti-inflammatory effects. We studied postoperative pain in 97 consecutive patients having photorefractive keratectomy (PRK) by an excimer laser with different topical NSAID protocols. Treatment with topical homatropine hydrobromide, either diclofenac sodium (Voltaren Ophthalmic) or ketorolac tromethamine (Acular), and a soft contact lens was most effective in achieving post-PRK analgesia. We also studied post-PRK myopic regression in 68 consecutive patients and found that flurbiprofen sodium (Ocufen), when added to topical steroid protocols, significantly reduced myopic regression for one year postoperatively more than steroids alone or steroids and diclofenac sodium. Diclofenac, used with topical steroids, had less of an additive effect on myopic regression than did flurbiprofen. Topical NSAIDs are useful adjuncts to PRK therapy, both to eliminate postoperative pain and to control post-PRK myopic regression.
非甾体抗炎药（NSAIDs）具有强效的镇痛、退热和抗炎作用。我们采用不同的局部NSAIDs方案，对97例连续接受准分子激光屈光性角膜切削术（PRK）的患者的术后疼痛进行了研究。使用局部氢溴酸后马托品、双氯芬酸钠（Voltaren Ophthalmic）或酮咯酸氨丁三醇（Acular）以及软性隐形眼镜进行治疗，在实现PRK术后镇痛方面最为有效。我们还对68例连续患者的PRK术后近视回退情况进行了研究，发现当在局部类固醇方案中添加氟比洛芬钠（Ocufen）时，与单独使用类固醇或类固醇与双氯芬酸钠相比，术后一年可显著减少近视回退。与局部类固醇联合使用时，双氯芬酸对近视回退的附加作用小于氟比洛芬。局部NSAIDs是PRK治疗的有用辅助药物，既能消除术后疼痛，又能控制PRK术后近视回退。
