RTC-硅酮颌面修复弹性体对细胞培养的影响。

Effects of RTC-silicone maxillofacial prosthetic elastomers on cell cultures.

作者信息

Polyzois G L, Hensten-Pettersen A, Kullman A

机构信息

Department of Prosthodontics, School of Dentistry, University of Athens, Greece.

出版信息

J Prosthet Dent. 1994 May;71(5):505-10. doi: 10.1016/0022-3913(94)90191-0.

DOI:10.1016/0022-3913(94)90191-0

PMID:8006848

Abstract

The use of a wide variety of materials in the construction of maxillofacial prostheses makes biocompatibility testing a necessity. However, the dental literature contains few reports of biocompatibility testing of maxillofacial prosthetic materials. The cytotoxic profiles of five room-temperature cross-linking (RTC)-silicone elastomers were investigated by means of two in vitro cell culture techniques. Mouse fibroblast cells (L929) were used, and the results indicated that RTC-silicone elastomers adversely affected cells in culture and that storage of samples for 1 week in saline solution did not alter this effect. Clinical follow-up of patients wearing prostheses made of these silicone materials is warranted to evaluate host reactions in long-term contact with human mucous membrane and skin tissue.

摘要

在颌面修复体的构建中使用多种材料使得生物相容性测试成为必要。然而，牙科文献中关于颌面修复材料生物相容性测试的报道很少。通过两种体外细胞培养技术研究了五种室温交联（RTC）硅橡胶弹性体的细胞毒性特征。使用了小鼠成纤维细胞（L929），结果表明RTC硅橡胶弹性体会对培养中的细胞产生不利影响，并且样品在盐溶液中储存1周不会改变这种影响。有必要对佩戴由这些硅橡胶材料制成的修复体的患者进行临床随访，以评估与人类黏膜和皮肤组织长期接触时的宿主反应。