Rocca P V, Siegel L B, Cupps T R
Department of Internal Medicine, Georgetown University Medical Center, Washington, DC 20007.
J Rheumatol. 1994 Mar;21(3):556-60.
We describe 4 patients with coagulopathy and vasculitis that demonstrated marked tissue ischemia and necrosis. In the clinical setting of rapid evolution of vascular insufficiency, the possibility of combined vasculopathic processes should be considered. This is especially so in patients with underlying connective tissue disease such as systemic lupus erythematosus or rheumatoid arthritis, in which both vasculitis and antiphospholipid antibodies are frequently present. Treatment of both pathologic processes may be required to prevent progressive tissue ischemia and necrosis. The use of antiplatelet and/or anticoagulation should be given consideration in addition to immunosuppressive agents.
我们描述了4例患有凝血病和血管炎的患者，这些患者表现出明显的组织缺血和坏死。在血管功能不全迅速发展的临床情况下，应考虑合并血管病变过程的可能性。在患有潜在结缔组织疾病（如系统性红斑狼疮或类风湿性关节炎）的患者中尤其如此，在这些疾病中血管炎和抗磷脂抗体经常同时存在。可能需要对这两种病理过程进行治疗，以防止组织缺血和坏死的进展。除免疫抑制剂外，还应考虑使用抗血小板药物和/或抗凝药物。
