Ishikura H, Kumagai F, Yoshiki T
Department of Pathology, Hokkaido University School of Medicine, Sapporo.
Jpn J Clin Oncol. 1994 Jun;24(3):175-80.
We report a rare case of carcinosarcoma of the ureter presented as a retroperitoneal tumor. The tumor originated in the ureter as a polypoid protrusion and spread around peri-ureteral, retroperitoneal tissues. The polypoid ureteral tumor was composed of an intra-epithelial carcinoma and a submucosal mesenchymal tumor; the histology of the retroperitoneal tumor in the original site was that of a carcinosarcoma. The bulk of the tumor in the retroperitoneum was composed of blastematous, epithelial and sarcomatous neoplastic cells with foci resembling an incomplete glomeruloid formation, thus mimicking a Wilms' tumor. The lesion appeared to originate from multipotential cells in the mucosal layer of the ureter. Whether or not this tumor has a true nephrogenic property is currently unknown. When a retroperitoneal tumor of the adult resembling a Wilms' tumor is found, one should suspect a possible carcinosarcomatous origin in the ureter.
我们报告一例罕见的输尿管癌肉瘤，表现为腹膜后肿瘤。肿瘤起源于输尿管，呈息肉样突出，并蔓延至输尿管周围、腹膜后组织。息肉样输尿管肿瘤由上皮内癌和黏膜下间叶肿瘤组成；原部位腹膜后肿瘤的组织学表现为癌肉瘤。腹膜后肿瘤的主体由母细胞性、上皮性和肉瘤性肿瘤细胞组成，有类似不完全肾小球样结构的病灶，因此类似肾母细胞瘤。该病变似乎起源于输尿管黏膜层的多能细胞。目前尚不清楚这种肿瘤是否具有真正的肾源性。当发现成人腹膜后肿瘤类似肾母细胞瘤时，应怀疑输尿管可能存在癌肉瘤起源。
