Sato A, Chida K
Second Department of Internal Medicine, Hamamatsu University School of Medicine.
Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Dec;31 Suppl:54-61.
To clarify the pathogenesis of idiopathic interstitial pneumonia (IIP), we compared the data of interstitial pneumonia (IP) associated with collagen vascular disease (CVD) with those of idiopathic pulmonary fibrosis (IPF). These disorders are found to have similar clinical, radiographic, and morphological findings, and lung function. However, the in vitro behavior of fibroblasts from CVD-IP and IPF, and the detection of soluble ICAM-1 were different. Further, in the T cell receptor repertoire, the predominance of different genes was found in bronchoalveolar lavage cells from CVD and IPF. These differences could partly explain the variability of IP pattern seen in CVD. In summary, our results indicate the possibility that CVD-IF and IPF result from different mechanisms although they share the same spectrum of pulmonary changes.
为阐明特发性间质性肺炎（IIP）的发病机制，我们将与胶原血管病（CVD）相关的间质性肺炎（IP）的数据与特发性肺纤维化（IPF）的数据进行了比较。发现这些疾病在临床、影像学、形态学表现及肺功能方面具有相似性。然而，CVD-IP和IPF来源的成纤维细胞的体外行为以及可溶性细胞间黏附分子-1（ICAM-1）的检测结果有所不同。此外，在T细胞受体库中，CVD和IPF的支气管肺泡灌洗细胞中不同基因的优势情况也不同。这些差异可以部分解释CVD中所见IP模式的变异性。总之，我们的结果表明，尽管CVD-IF和IPF具有相同的肺部变化谱，但它们可能由不同机制导致。
